The rapid accumulation of genome sequence data has made phylogenetics an indispensable tool to various branches of biology. However, it has also posed considerable statistical and computational ...

Although epistasis is an important phenomenon in the genetics and evolution of complex traits, epistatic effects are hard to estimate. The main problem is due to the overparameterized epistatic ...

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The likelihood equation for a logistic regression model does not always have a finite solution. Sometimes there is a nonunique maximum on the boundary of the parameter space, at infinity. The ...